Regressor-guided Diffusion Model for De Novo Peptide Sequencing with Explicit Mass Control

Shaorong Chen; Jingbo Zhou; Jun Xia

AAAI 2026technical0 citations

Regressor-guided Diffusion Model for De Novo Peptide Sequencing with Explicit Mass Control

Abstract

The discovery of novel proteins relies on sensitive protein identification, for which de novo peptide sequencing (DNPS) from mass spectra is a crucial approach. While deep learning has advanced DNPS, existing models inadequately enforce the fundamental mass consistency constraint—that a predicted peptide

BibTeX

@inproceedings{aaai2026_regressorguidedd,
  title = {Regressor-guided Diffusion Model for De Novo Peptide Sequencing with Explicit Mass Control},
  author = {Shaorong Chen and Jingbo Zhou and Jun Xia},
  booktitle = {AAAI 2026},
  year = {2026}
}