PoinnCARE: Hyperbolic Multi-Modal Learning for Enzyme Classification
Kun XIE, Peng Zhou, Xingyi Zhang, Wei Liu, Peilin Zhao, Sibo Wang, Biaobin Jiang
Abstract
Enzyme Commission (EC) number prediction is vital for elucidating enzyme functions and advancing biotechnology applications. However, current methods struggle to capture the hierarchical relationships among enzymes and often overlook critical structural and active site features. To bridge this gap, we introduce PoinnCARE, a novel framework that jointly encodes and aligns multi-modal data from enzyme sequences, structures, and active sites in hyperbolic space. By integrating graph diffusion and alignment techniques, PoinnCARE mitigates data sparsity and enriches functional representations, while hyperbolic embedding preserves the intrinsic hierarchy of the EC system with theoretical guarantees in low-dimensional spaces. Extensive experiments on four datasets from the CARE benchmark demonstrate that PoinnCARE consistently and significantly outperforms state-of-the-art methods in EC number prediction.
BibTeX
@inproceedings{
xie2026poinncare,
title={Poinn{CARE}: Hyperbolic Multi-Modal Learning for Enzyme Classification},
author={Kun XIE and Peng Zhou and Xingyi Zhang and Wei Liu and Peilin Zhao and Sibo Wang and Biaobin Jiang},
booktitle={The Fourteenth International Conference on Learning Representations},
year={2026},
url={https://openreview.net/forum?id=dGxAYNK6JU}
}