FLIQA-AD: a Fusion Model with Large Language Model for Better Diagnose and MMSE Prediction of Alzheimer’s Disease

Abstract

Tracking a patient’s cognitive status early in the onset of the disease provides an opportunity to diagnose and intervene in Alzheimer’s disease (AD). However, relying solely on magnetic resonance imaging (MRI) images with traditional classification and regression models may not fully extract finer-grained information. This study proposes a multi-task Fusion Language Image Question Answering model (FLIQA-AD) to perform AD identification and Mini Mental State Examination (MMSE) prediction. Specifically, a 3D Adapter is introduced in Vision Transformer (ViT) model for image feature extraction. The patient electronic health records (EHR) information and questions related to the disease work as text prompts to be encoded. Then, an ADFormer model, which combines self-attention and cross-attention mechanisms, is used to capture the correlation between EHR information and structure features. After that, the extracted brain structural information and textual content are combined as input sequences for the large language model (LLM) to identify AD and predict the corresponding MMSE score. Experimental results demonstrate the strong discrimination and MMSE prediction performance of the model, as well as question-answer capabilities.