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Alexander S Powers

2 accepted papers

2024

Aligning Target-Aware Molecule Diffusion Models with Exact Energy Optimization

NeurIPS 2024poster

Generating ligand molecules for specific protein targets, known as structure-based drug design, is a fundamental problem in therapeutics development and biological discovery. Recently, target-aware generative models, especially diffusion models, have shown great promise in modeling protein-ligand in…

2023

Geometric Latent Diffusion Models for 3D Molecule Generation

ICML 2023poster

Generative models, especially diffusion models (DMs), have achieved promising results for generating feature-rich geometries and advancing foundational science problems such as molecule design. Inspired by the recent huge success of Stable (latent) Diffusion models, we propose a novel and principled…