Andrew Kirjner — accepted AI-conference papers

2025

ConnectomeBench: Can LLMs proofread the connectome?

Jeff Brown, Andrew Kirjner, Annika Vivekananthan, Edward Boyden

NeurIPS 2025spotlight

Connectomics—the mapping of neural connections in an organism's brain—currently requires extraordinary human effort to proofread the data collected from imaging and machine-learning assisted segmentation. With the growing excitement around using AI agents to automate important scientific tasks, we e…

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2024

Improving protein optimization with smoothed fitness landscapes

Andrew Kirjner, Jason Yim, Raman Samusevich, Shahar Bracha, Tommi S. Jaakkola, Regina Barzilay +1

ICLR 2024poster

The ability to engineer novel proteins with higher fitness for a desired property would be revolutionary for biotechnology and medicine. Modeling the combinatorially large space of sequences is infeasible; prior methods often constrain optimization to a small mutational radius, but this drastically…

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