Bruce James Wittmann — accepted AI-conference papers

2025

Steering Generative Models with Experimental Data for Protein Fitness Optimization

Jason Yang, Wenda Chu, Daniel Khalil, Raul Astudillo, Bruce James Wittmann, Frances H. Arnold +1

NeurIPS 2025poster

Protein fitness optimization involves finding a protein sequence that maximizes desired quantitative properties in a combinatorially large design space of possible sequences. Recent advances in steering protein generative models (e.g., diffusion models and language models) with labeled data offer a…

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2024

CARE: a Benchmark Suite for the Classification and Retrieval of Enzymes

Jason Yang, Ariane Mora, Shengchao Liu, Bruce James Wittmann, Anima Anandkumar, Frances H. Arnold +1

NeurIPS 2024poster

Enzymes are important proteins that catalyze chemical reactions. In recent years, machine learning methods have emerged to predict enzyme function from sequence; however, there are no standardized benchmarks to evaluate these methods. We introduce CARE, a benchmark and dataset suite for the Classif…

Cited by 5 Source ↗PDF ↗code ↗Scholar ↗