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David A. Knowles

3 accepted papers

2026

Interpretable Neural ODEs for Gene Regulatory Network Discovery under Perturbations

ICML 2026poster

Modern high-throughput biological datasets containing thousands of perturbations enable large-scale discovery of causal graphs that represent regulatory interactions between genes. Differentiable causal graphical models and regression-based methods have been developed to infer gene regulatory networ…

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2024

Disentangling Interpretable Factors with Supervised Independent Subspace Principal Component Analysis

NeurIPS 2024poster

The success of machine learning models relies heavily on effectively representing high-dimensional data. However, ensuring data representations capture human-understandable concepts remains difficult, often requiring the incorporation of prior knowledge and decomposition of data into multiple subspa…