2025
Generalists vs. Specialists: Evaluating LLMs on Highly-Constrained Biophysical Sequence Optimization Tasks
Angelica Chen, Samuel Don Stanton, Frances Ding, Robert G Alberstein, Andrew Martin Watkins, Richard Bonneau +3
ICML 2025poster
Although large language models (LLMs) have shown promise in biomolecule optimization problems, they incur heavy computational costs and struggle to satisfy precise constraints. On the other hand, specialized solvers like LaMBO-2 offer efficiency and fine-grained control but require more domain exper…