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Guanlue Li

2 accepted papers

2026

Proteo-R1: Thinking Foundation Models for De Novo Protein Binder Design

ICML 2026poster

Recent advances in generative diffusion and flow-matching models have revolutionized molecular design, enabling the creation of novel proteins, small molecules, and RNA sequences with unprecedented fidelity. Yet, these models remain intuitive rather than intelligent—they generate without reasoning. …

Cited by 0SourceScholar
2025

Joint Design of Protein Surface and Backbone Using a Diffusion Bridge Model

NeurIPS 2025poster

Protein-protein interactions (PPIs) are governed by surface complementarity and hydrophobic interactions at protein interfaces. However, designing diverse and physically realistic protein structure and surfaces that precisely complement target receptors remains a significant challenge in computation…

Cited by 0SourceScholar