5 accepted papers
Diffusion and flow matching models have recently emerged as promising approaches for peptide binder design. Despite their progress, these models still face two major challenges. First, categorical sampling of discrete residue types collapses their continuous parameters into one-hot assignments, whil
Automating end-to-end GPU kernel generation with Large Language Models (LLMs) faces a critical tension between global performance and exploration efficiency. We present LEGO, a hierarchical framework that resolves this trade-off via a parallel multi-agent search over a recursive AND-OR FusionTree. L…
Structure-based drug design (SBDD), aiming to generate 3D molecules with high binding affinity toward target proteins, is a vital approach in novel drug discovery. Although recent generative models have shown great potential, they suffer from unstable probability dynamics and mismatch between genera…
Crafting a convincing financial market analysis report necessitates a wealth of market information and the expertise of financial analysts, posing a highly challenging task. While large language models (LLMs) have enabled the automated generation of financial market analysis text, they still face is…
The stock market is a crucial component of the financial system, but predicting the movement of stock prices is challenging due to the dynamic and intricate relations arising from various aspects such as economic indicators, financial reports, global news, and investor sentiment. Traditional sequent…