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John Quackenbush

4 accepted papers

2024

Pruning neural network models for gene regulatory dynamics using data and domain knowledge

NeurIPS 2024poster

The practical utility of machine learning models in the sciences often hinges on their interpretability. It is common to assess a model's merit for scientific discovery, and thus novel insights, by how well it aligns with already available domain knowledge - a dimension that is currently largely dis…

2021

Cascade Size Distributions: Why They Matter and How to Compute Them Efficiently

AAAI 2021technical

Cascade models are central to understanding, predicting, and controlling epidemic spreading and information propagation. Related optimization, including influence maximization, model parameter inference, or the development of vaccination strategies, relies heavily on sampling from a model. This is e…

2021

Gene Regulatory Network Inference as Relaxed Graph Matching

AAAI 2021technical

Bipartite network inference is a ubiquitous problem across disciplines. One important example in the field molecular biology is gene regulatory network inference. Gene regulatory networks are an instrumental tool aiding in the discovery of the molecular mechanisms driving diverse diseases, including…

Cited by 27SourcePDFScholar
2021

Scaling up Continuous-Time Markov Chains Helps Resolve Underspecification

NeurIPS 2021poster

Modeling the time evolution of discrete sets of items (e.g., genetic mutations) is a fundamental problem in many biomedical applications. We approach this problem through the lens of continuous-time Markov chains, and show that the resulting learning task is generally underspecified in the usual set…

Cited by 12SourcePDFScholar