M. Sierra-Castrillón

Acoustic and Linguistic Analyses to Assess Early-Onset and Genetic Alzheimer's Disease

The PSEN1-E280A or Paisa mutation is responsible for most of Early-Onset Alzheimer’s (EOA) disease cases in Colombia. It affects a large kindred of over 5000 members that present the same phenotype. The most common symptoms are related to language disorders, where speech fluency is also affected due…