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Mohammad Lotfollahi

3 accepted papers

2026

DirMoE: Dirichlet-Routed Mixture of Experts

ICLR 2026poster

Mixture-of-Experts (MoE) models have demonstrated exceptional performance in large-scale language models. Existing routers typically rely on non-differentiable Top-$k$+Softmax, limiting their performance and scalability. We argue that two distinct decisions, which experts to activate and how to dist…

Cited by 0SourceScholar
2026

Many Needles in a Haystack: Active Hit Discovery for Perturbation Experiments

ICML 2026poster

High-throughput gene perturbation experiments can test several genetic interventions in parallel, yet experimental budgets remain limited. A central goal is hit discovery: identifying as many perturbations as possible whose phenotypic effect exceeds a predefined threshold. Pure exploration strategie…

Cited by 0SourceScholar
2022

Predicting Cellular Responses to Novel Drug Perturbations at a Single-Cell Resolution

NeurIPS 2022accept

Single-cell transcriptomics enabled the study of cellular heterogeneity in response to perturbations at the resolution of individual cells. However, scaling high-throughput screens (HTSs) to measure cellular responses for many drugs remains a challenge due to technical limitations and, more importan…