Ngoc-Quang Nguyen

PepTri: Tri-Guided All-Atom Diffusion for Peptide Design via Physics, Evolution, and Mutual Information

Peptides, short chains of amino acids capable of high-specificity protein binding, represent a powerful class of therapeutics. While deep generative models have shown promise for peptide design, existing approaches are often structure-centric and therefore generate sequences and structures in a deco…