2026
A One-shot Framework for Directed Evolution of Antibodies
Sai Pooja Mahajan, Natasa Tagasovska, Stefania Vasilaki, Arian Rokkum Jamasb, Andrew Martin Watkins, Rajesh Ranganath
ICLR 2026poster
Improving antibody binding to an antigen without antibody-antigen structure information or antigen-specific data remains a critical challenge in therapeutic protein design. In this work, we propose \textbf{\textsc{AffinityEnhancer}}, a framework to improve the affinity of an antibody in a one-shot s…