Sazan Mahbub

PRISM: Enhancing PRotein Inverse Folding through Fine- Grained Retrieval on Structure-Sequence Multimodal Representations

Designing protein sequences that fold into a target 3-D structure, termed as the inverse folding problem, is central to protein engineering. However, it remains challenging due to the vast sequence space and the importance of local structural constraints. Existing deep learning approaches achieve st…