7 accepted papers
Protein family design emerges as a promising alternative by combining the advantages of de novo protein design and mutation-based directed evolution.In this paper, we propose ProfileBFN, the Profile Bayesian Flow Networks, for specifically generative modeling of protein families. ProfileBFN extends…
Protein language models have demonstrated significant potential in the field of protein engineering. However, current protein language models primarily operate at the residue scale, which limits their ability to provide information at the atom level. This limitation prevents us from fully exploiting…
3D molecular representation learning has gained tremendous interest and achieved promising performance in various downstream tasks. A series of recent approaches follow a prevalent framework: an encoder-only model coupled with a coordinate denoising objective. However, through a series of analytical…
Target-oriented multimodal sentiment classification (TMSC) is a new subtask of aspect-based sentiment analysis, which aims to determine the sentiment polarity of the opinion target mentioned in a (sentence, image) pair. Recently, dominant works employ the attention mechanism to capture the correspon…
Drug design is a crucial step in the drug discovery cycle. Recently, various deep learning-based methods design drugs by generating novel molecules from scratch, avoiding traversing large-scale drug libraries. However, they depend on scarce experimental data or time-consuming docking simulation, lea…
Large-scale multi-label text classification (LMTC) tasks often face long-tailed label distributions, where many labels have few or even no training instances. Although current methods can exploit prior knowledge to handle these few/zero-shot labels, they neglect the meta-knowledge contained in the d…
Machine reading comprehension (MRC) is the task that asks a machine to answer questions based on a given context. For Chinese MRC, due to the non-literal and non-compositional semantic characteristics, Chinese idioms pose unique challenges for machines to understand. Previous studies tend to treat i…