3 accepted papers
Antibodies are central proteins in adaptive immune responses, responsible for protecting against viruses and other pathogens. Rational antibody design has proven effective in the diagnosis and treatment of various diseases like cancers and virus infections. While recent diffusion-based generative mo…
De novo protein design aims to create novel protein structures and sequences unseen in nature. Recent structure-oriented design methods typically employ a two-stage strategy, where structure design and sequence design modules are trained separately, and the backbone structures and sequences are gene…
Many crucial biological processes rely on networks of protein-protein interactions. Predicting the effect of amino acid mutations on protein-protein binding is important in protein engineering, including therapeutic discovery. However, the scarcity of annotated experimental data on binding energy po…