5 accepted papers
Value decomposition is a central approach in multi-agent reinforcement learning (MARL), enabling centralized training with decentralized execution by factorizing the global value function into local values. To ensure individual-global-max (IGM) consistency, existing methods either enforce monotonici
Designing RNA sequences that reliably fold into specific secondary structures is essential for understanding their biological functions but remains a challenging computational problem. We propose CocoRNA, a cooperative multi-agent reinforcement learning framework for RNA inverse design. CocoRNA simp…
Multi-objective reinforcement learning (MORL) seeks policies that effectively balance conflicting objectives. However, presenting many diverse policies without accounting for the decision maker’s (DM’s) preferences can overwhelm the decision-making process. On the other hand, accurately specifying p…
The inverse design of RNA three-dimensional (3D) structures is crucial for engineering functional RNAs in synthetic biology and therapeutics. While recent deep learning approaches have advanced this field, they are typically optimized and evaluated using native sequence recovery, which is a limited…
Multi-objective reinforcement learning (MORL) provides an effective solution for decision-making problems involving conflicting objectives. However, achieving high-quality approximations to the Pareto policy set remains challenging, especially in complex tasks with continuous or high-dimensional sta…