Xinye Zheng

Multimodal Protein Language Models for Enzyme Kinetic Parameters: From Substrate Recognition to Conformational Adaptation

Predicting enzyme kinetic parameters quantifies how efficiently an enzyme catalyzes a specific substrate under defined biochemical conditions. Canonical parameters such as the turnover number (k_\text cat ), Michaelis constant (K_\text m ), and inhibition constant (K_\text i ) depend jointly on the