Yaoxing Wu

PScalpel: A Machine Learning-based Guider for Protein Phase-Separating Behaviour Alteration

Missense mutations could affect the Liquid-Liquid Phase Separation (LLPS) propensity of proteins and lead to aberrant phase-separating behaviours, which are recently found to be associated with many diseases including Alzheimer's and cancer. However, the regulatory role of mutations in LLPS remains…