Ye-Fan Hu

TOPOBIND: MULTI-MODAL PREDICTION OF ANTIBODY-ANTIGEN BINDING FREE ENERGY VIA SEQUENCE EMBEDDINGS AND STRUCTURAL TOPOLOGY

Predicting the binding free energy between antibodies and antigens is a key challenge in structure-aware biomolecular modeling, with direct implications for antibody design. Most existing methods either rely solely on sequence embeddings or struggle to capture complex structural relationships, thus…