10 accepted papers
Large language models (LLMs) have revolutionized natural language processing and are increasingly applied to other sequential data types, including genetic sequences. However, adapting LLMs to genetics presents significant challenges. Capturing complex genomic interactions requires modeling long-ran…
Designing protein-binding proteins with high affinity is critical in biomedical research and biotechnology. Despite recent advancements targeting specific proteins, the ability to create high-affinity binders for arbitrary protein targets on demand, without extensive rounds of wet-lab testing, remai…
Enzymes are genetically encoded biocatalysts capable of accelerating chemical reactions. How can we automatically design functional enzymes? In this paper, we propose EnzyGen, an approach to learn a unified model to design enzymes across all functional families. Our key idea is to generate an enzyme…
How can large language models (LLMs) process and translate endangered languages? Many languages lack a large corpus to train a decent LLM; therefore existing LLMs rarely perform well in unseen, endangered languages. On the contrary, we observe that 2000 endangered languages, though without a large c…
Nucleic acid-based drugs like aptamers have recently demonstrated great therapeutic potential. However, experimental platforms for aptamer screening are costly, and the scarcity of labeled data presents a challenge for supervised methods to learn protein-aptamer binding. To this end, we develop an u…
How can we design proteins with desired functions? We are motivated by a chemical intuition that both geometric structure and biochemical properties are critical to a protein's function. In this paper, we propose SurfPro, a new method to generate functional proteins given a desired surface and its a…
Automatically evaluating the quality of language generation is critical. Although recent learned metrics show high correlation with human judgement, these metrics do not provide explicit explanation of their verdict, nor associate the scores with defects in the generated text. To address this limita…
Designing protein sequences with desired biological function is crucial in biology and chemistry. Recent machine learning methods use a surrogate sequence-function model to replace the expensive wet-lab validation. How can we efficiently generate diverse and novel protein sequences with high fitness…
We introduce MTG, a new benchmark suite for training and evaluating multilingual text generation. It is the first-proposed multilingual multiway text generation dataset with the largest human-annotated data (400k). It includes four generation tasks (story generation, question generation, title gener…
Multilingual machine translation aims to develop a single model for multiple language directions. However, existing multilingual models based on Transformer are limited in terms of both translation performance and inference speed. In this paper, we propose switch-GLAT, a non-autoregressive multiling…