2024
Designing Cell-Type-Specific Promoter Sequences Using Conservative Model-Based Optimization
Aniketh Janardhan Reddy, Xinyang Geng, Michael H Herschl, Sathvik Kolli, Aviral Kumar, Patrick D Hsu +2
NeurIPS 2024poster
Gene therapies have the potential to treat disease by delivering therapeutic genetic cargo to disease-associated cells. One limitation to their widespread use is the lack of short regulatory sequences, or promoters, that differentially induce the expression of delivered genetic cargo in target cells…