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Arvind Rajpal

2 accepted papers

2023

AbDiffuser: full-atom generation of in-vitro functioning antibodies

NeurIPS 2023spotlight

We introduce AbDiffuser, an equivariant and physics-informed diffusion model for the joint generation of antibody 3D structures and sequences. AbDiffuser is built on top of a new representation of protein structure, relies on a novel architecture for aligned proteins, and utilizes strong diffusion p…

Cited by 52SourcePDFScholar
2023

Protein Design with Guided Discrete Diffusion

NeurIPS 2023spotlight

A popular approach to protein design is to combine a generative model with a discriminative model for conditional sampling. The generative model samples plausible sequences while the discriminative model guides a search for sequences with high fitness. Given its broad success in conditional sampling…