Francis Leblanc

Needles in the Haystack: Addressing Signal Dilution Improves scRNA-seq Perturbation Response Modeling and Evaluation

Recent benchmarks reveal that single-cell perturbation response models are often outperformed by simply predicting the dataset mean. Through large-scale *in silico* simulations, together with analyses of two real-world perturbation datasets, we trace this anomaly to a metric artifact: unweighted err…