Haley Smith

Quantifying Cross-Attention Interaction in Transformers for Interpreting TCR-pMHC Binding

CD8+ “killer” T cells and CD4+ “helper” T cells play a central role in the adaptive immune system by recognizing antigens presented by Major Histocompatibility Complex (pMHC) molecules via T Cell Receptors (TCRs). Modeling binding between T cells and the pMHC complex is fundamental to understanding…