2026
ProtSAE: Disentangling and Interpreting Protein Language Models via Semantically-Guided Sparse Autoencoders
AAAI 2026technical
Sparse Autoencoder (SAE) has emerged as a powerful tool for mechanistic interpretability of large language models. Recent works apply SAE to protein language models (PLMs), aiming to extract and analyze biologically meaningful features from their latent spaces. However, SAE suffers from semantic en