3 accepted papers
Modeling single-cell gene expression across diverse biological and technical conditions is essential for understanding cellular states and simulating unobserved scenarios. We present SAVE, a unified generative framework for multi-condition single-cell modeling. SAVE combines a variational autoencode…
Single-cell perturbation modeling is fundamental for understanding and predicting cellular responses to genetic perturbations. However, existing approaches, from causal representation learning to foundation models, often struggle with an overlooked challenge: gene expression is dominated by perturba…
Single-cell sequencing technology provides deep insights into gene activity at the individual cell level, facilitating the study of gene regulatory mechanisms. However, observed gene expression are often influenced by confounding factors such as batch effects, perturbations, and spatial position, wh