5 accepted papers
Phase I clinical trials are designed to test the safety (non-toxicity) of drugs and find the maximum tolerated dose (MTD). This task becomes significantly more challenging when multiple-drug dose-combinations (DC) are involved, due to the inherent conflict between the exponentially increasing DC can…
Machine learning has proved its ability to produce accurate models -- but the deployment of these models outside the machine learning community has been hindered by the difficulties of interpreting these models. This paper proposes an algorithm that produces a continuous global interpretation of any…
Subgroup analysis of treatment effects plays an important role in applications from medicine to public policy to recommender systems. It allows physicians (for example) to identify groups of patients for whom a given drug or treatment is likely to be effective and groups of patients for which it is…
The importance of survival analysis in many disciplines (especially in medicine) has led to the development of a variety of approaches to modeling the survival function. Models constructed via various approaches offer different strengths and weaknesses in terms of discriminative performance and cali…
Screening is important for the diagnosis and treatment of a wide variety of diseases. A good screening policy should be personalized to the disease, to the features of the patient and to the dynamic history of the patient (including the history of screening). The growth of electronic health recor…