2026
EpiCoCo: De Novo Epitope Generation via MHC-Context Co-Modeling and Contrastive Affinity Guidance
ICML 2026poster
The *de novo* generation of high-affinity epitopes tailored to specific major histocompatibility complex (MHC) proteins is a pivotal challenge in computational immunotherapy. However, current methods struggle to effectively integrate the MHC context into the generation process, and often fail to gua…