Zhaoming Chen — accepted AI-conference papers

2026

EPO: Diverse and Realistic Protein Ensemble Generation via Energy Preference Optimization

Yuancheng Sun, Yuxuan Ren, Zhaoming Chen, Xu Han, Kang Liu, Qiwei Ye

AAAI 2026technical

Accurate exploration of protein conformational ensembles is essential for uncovering function but remains hard because molecular-dynamics (MD) simulations suffer from high computational costs and energy-barrier trapping. This paper presents Energy Preference Optimization (EPO), an online refinement

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2025

CryoGEN: Generative Energy-based Models for Cryogenic Electron Tomography Reconstruction

Yunfei Teng, Yuxuan Ren, Kai Chen, Xi Chen, Zhaoming Chen, Qiwei Ye

ICLR 2025poster

Cryogenic electron tomography (Cryo-ET) is a powerful technique for visualizing subcellular structures in their native states. Nonetheless, its effectiveness is compromised by anisotropic resolution artifacts caused by the missing-wedge effect. To address this, IsoNet, a deep learning-based method,…

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