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Manolis Kellis

4 accepted papers

2026

Greater than the Sum of Its Parts: Building Substructure into Protein Encoding Models

ICLR 2026poster

Protein representation learning has achieved major advances using large sequence and structure datasets, yet current models primarily operate at the level of individual residues or entire proteins. This overlooks a critical aspect of protein biology: proteins are composed of recurrent, evolutionaril…

Cited by 0SourceScholar
2026

SPATIA: Multimodal Generation and Prediction of Spatial Cell Phenotypes

ICML 2026poster

Understanding how cellular morphology, gene expression, and spatial context jointly shape tissue function is a central challenge in biology. Image-based spatial transcriptomics technologies now provide high-resolution measurements of cell images and gene expression profiles, but existing methods typ…

Cited by 0SourceScholar
2024

A versatile informative diffusion model for single-cell ATAC-seq data generation and analysis

NeurIPS 2024poster

The rapid advancement of single-cell ATAC sequencing (scATAC-seq) technologies holds great promise for investigating the heterogeneity of epigenetic landscapes at the cellular level. The amplification process in scATAC-seq experiments often introduces noise due to dropout events, which results in ex…

Cited by 0SourcePDFScholar
2024

Position: TrustLLM: Trustworthiness in Large Language Models

ICML 2024poster

Large language models (LLMs) have gained considerable attention for their excellent natural language processing capabilities. Nonetheless, these LLMs present many challenges, particularly in the realm of trustworthiness. This paper introduces TrustLLM, a comprehensive study of trustworthiness in LLM…

Cited by 95SourcePDFScholar