3 accepted papers
Predicting protein mutation effects is fundamental to protein engineering and disease variant interpretation, yet experimental mutation data remain accurate but extremely sparse. Large-scale computational augmentation offers scalability, but introduces heterogeneous and poorly calibrated supervision…
We introduce a framework for designing efficient diffusion models for $d$-dimensional symmetric-space Riemannian manifolds, including the torus, sphere, special orthogonal group and unitary group. Existing manifold diffusion models often depend on heat kernels, which lack closed-form expressions an…
Frontier large language models (LLMs) have shown great success in text modeling and generation tasks across domains. However, natural language exhibits inherent semantic hierarchies and nuanced geometric structure, which current LLMs do not capture completely owing to their reliance on Euclidean ope…