6 accepted papers
Accurate prediction of compound protein interactions (CPIs) is crucial for drug discovery. However, existing deep learning-based methods suffer from hidden biases and poor cross-domain generalization, leading to spurious correlations and inadequate representation of unseen compound-protein pairs.
Predicting drug–target interactions (DTIs) is a fundamental task in computational drug discovery, yet it remains challenging under distribution shifts and limited training data. Existing approaches often suffer from poor generalization, weak cross-modal alignment between molecular and protein repres
Achieving robust vision-based humanoid locomotion remains challenging due to two fundamental issues: the sim-toreal gap introduces significant perception noise that degrades performance on fine-grained tasks, and training a unified policy across diverse terrains is hindered by conflicting learning o…
With the rapid advance of spatial multi-omics technologies, it has become possible to simultaneously profile transcripts, proteins and chromatin states at their native spatial coordinates, thereby uncovering molecular architecture that transcends any single-omics perspective. However, the resulting
Learning a universal manipulation policy encompassing doors with diverse categories, geometries and mechanisms, is crucial for future embodied agents to effectively work in complex and broad real-world scenarios. Due to the limited datasets and unrealistic simulation environments, previous studies f…
Human brains are commonly modeled as networks of Regions of Interest (ROIs) and their connections for the understanding of brain functions and mental disorders. Recently, Transformer-based models have been studied over different types of data, including graphs, shown to bring performance gains widel…