Chenao Li

2 accepted papers

2026

FlexProtein: Joint Sequence and Structure Pretraining for Protein Modeling

Jianwei Zhu, Yu Shi, Ran Bi, Peiran Jin, Chang Liu, Zhe Zhang +17

ICLR 2026poster

Protein foundation models have advanced rapidly, with most approaches falling into two dominant paradigms. Sequence-only language models (e.g., ESM-2) capture sequence semantics at scale but lack structural grounding. MSA-based predictors (e.g., AlphaFold 2/3) achieve accurate folding by exploiting…

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2025

UniZyme: A Unified Protein Cleavage Site Predictor Enhanced with Enzyme Active-Site Knowledge

Chenao Li, Shuo Yan, Enyan Dai

NeurIPS 2025poster

Enzyme-catalyzed protein cleavage is essential for many biological functions. Accurate prediction of cleavage sites can facilitate various applications such as drug development, enzyme design, and a deeper understanding of biological mechanisms. However, most existing models are restricted to an ind…

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