19 accepted papers
3D molecular linker design is a critical task in structure-based drug discovery, which requires the precise synthesis of chemical bridges to connect fragments within the constrained environment of a protein binding pocket. Existing methods often suffer from environmental blindness, treating the inte
Drug combinations are widely used in modern medicine but may cause severe adverse drug reactions. Therefore, making effective drug-drug interactions (DDI) prediction is crucial for pharmacovigilance. Existing DDI prediction models are typically built from a structural perspective, assuming that drug
Existing spatial domain identification methods primarily use graph neural networks to model spatial and transcriptional relationships. However, their performance is highly sensitive to noisy affinity graphs. Moreover, graph autoencoders tend to over-constrain latent representations, which limits the
Incomplete multi-view clustering (IMVC) aims to group data into meaningful clusters when each sample is only partially observed across multiple views. Most existing methods either rely on imputation strategies that may introduce noise and distort the underlying data distribution, or adopt cross-view
Incomplete multi-view clustering is challenging due to view missingness and the entanglement of shared semantics with view-specific factors in latent representations. Existing methods often rely on heuristic fusion or direct completion strategies, which suffer from error propagation and unreliable g…
Whole-slide images (WSIs) provide gigapixel-scale visual evidence for cancer diagnosis, yet diagnostically relevant regions are typically sparse and embedded within large amounts of weakly informative tissue. Existing multiple instance learning methods often aggregate all patches by using attention
Vision foundation models (e.g., SAM2, CLIP) show strong generalization in natural image analysis but degrade significantly in specialized domains like medical imaging. This is critical for tasks such as brain tumor segmentation, where errors directly affect surgical planning and patient outcomes. In
Molecular representation plays a central role in computational drug discovery. Pharmacophores, functional groups responsible for molecular bioactivity, have been widely studied in cheminformatics. However, their incorporation into molecular representation learning, particularly in a context reasonin
In natural scenarios, vision models often encounter the challenge of complex degradation scenarios(e.g., rain, snow, fog, or motion blur). These degradations severely corrupt image features, causing existing models to treat rarely seen or unseen degraded images as “unfamiliar”, thereby losing their
Depth enhancement, which uses RGB images as guidance to convert raw signals from dToF into high-precision, dense depth maps, is a critical task in computer vision. Although existing super-resolution-based methods show promising results on public datasets, they often rely on idealized assumptions lik…
Cross-modal representation learning aims to extract semantically aligned representations from heterogeneous modalities such as images and text. Existing multimodal VAE-based models often suffer from limited capability to align heterogeneous modalities or lack sufficient structural constraints to cle…
Accurately modeling the target-drug complex at atom level presents a significant challenge in the computer-aided drug design. Traditional methods that rely solely on rigid transformations often fail to capture the adaptive interactions between targets and drugs, particularly during substantial confo…
Spatial transcriptomics integrates spatial, gene expression, and multichannel immunohistochemistry image data, enabling advanced insights into cellular organization. However, existing methods often struggle to effectively fuse these multimodal data, limiting their potential for accurate spatial doma
Development of robust and effective strategies for retrosynthetic planning requires a deep understanding of the synthesis process. A critical step in achieving this goal is accurately identifying synthetic intermediates. Current machine learning-based methods often overlook the valuable context from…
Lightweight direct Time-of-Flight (dToF) sensors are ideal for 3D sensing on mobile devices. However, due to the manufacturing constraints of compact devices and the inherent physical principles of imaging, dToF depth maps are sparse and noisy. In this paper, we propose a novel video depth completio…
In recent years, significant progress has been made in prototype-based learning methods for few-shot semantic segmentation. However, prototype features originating from the support images are interfered with by intra-class diversity and thus cannot be aligned with the query foreground, resulting in…
Accurate segmentation of lesions is crucial for disease diagnosis and treatment planning. However, blurring and low contrast in the imaging process can affect segmentation results. We have observed that noninvasive medical imaging shares considerable similarities with natural images under low light
The multi-armed bandit(MAB) is a classical sequential decision problem. Most work requires assumptions about the reward distribution (e.g., bounded), while practitioners may have difficulty obtaining information about these distributions to design models for their problems, especially in non-stati…
We propose a novel style transfer method to quickly create a new visual product with a nice appearance for industrial designers' reference. Given a source product, a target product, and an art style image, our method produces a neural warping field that warps the source shape to imitate the geometri…