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Qihe Chen

4 accepted papers

2026

CryoACE: An Atom-centric Framework for Accurate and Automated Model Building in Cryo-EM

ICML 2026poster

Protein automodeling from cryo-EM density maps faces unique challenges in enforcing physicochemical validity and managing conformational heterogeneity. Current solvers are often limited to static predictions or require computationally intensive heuristic searches. We present CryoACE, an end-to-end f…

Cited by 0SourceScholar
2024

CryoGEM: Physics-Informed Generative Cryo-Electron Microscopy

NeurIPS 2024poster

In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is crucial in resolving near-atomic resolution 3D structures of prot…

Cited by 0SourcePDFScholar
2024

DRACO: A Denoising-Reconstruction Autoencoder for Cryo-EM

NeurIPS 2024poster

Foundation models in computer vision have demonstrated exceptional performance in zero-shot and few-shot tasks by extracting multi-purpose features from large-scale datasets through self-supervised pre-training methods. However, these models often overlook the severe corruption in cryogenic electron…

Cited by 1SourcePDFScholar