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Masahiro Nakajima

12 accepted papers

2017

High-precision microinjection of microbeads into C. elegans trapped in a suction microchannel

Masahiro Nakajima, Yuki Ayamura, Masaru Takeuchi, Naoki Hisamoto, Strahil Pastuhov, Yasuhisa Hasegawa +2
ICRA 2017poster

This study presents the high-precision microinjection of fluorescent micro-gel beads into Caenorhabditis elegans trapped in a suction microchannel. In our previous works, we demonstrated survival microinjection by a conventional micromanipulation technique. However, the focal planes differed between…

Cited by 8Source ↗Scholar ↗
2017

Multi-Layered Channel Patterning by Local Heating of Hydrogels

Masaru Takeuchi, Tomoyuki Oya, Akihiko Ichikawa, Akiyuki Hasegawa, Masahiro Nakajima, Yasuhisa Hasegawa +1
RA-L 2017

In this letter, we conducted a new method to fabricate channels inside cell structures for tissue engineering applications. A cell-embedded hydrogel is locally melted to fabricate channels inside cell structures. The fabricated channels can be used as vascular-like networks to supply nutrition and o

Cited by 0Source ↗Scholar ↗
2017

Robotics-based micro-reeling of magnetic microfibers to fabricate helical structure for smooth muscle cells culture

Tao Sun, Qing Shi, Huaping Wang, Xiaoming Liu, Chengzhi Hu, Masahiro Nakajima +2
ICRA 2017poster

Helical structure assembled by hydrogel microfibers is significant for culture of smooth muscle cells. However, the helical structure is only fabricated at the macroscale, while the fabrication of helical microstructure is still a challenge due to the lack of assembly method. In this paper, we propo…

Cited by 2Source ↗Scholar ↗
2016

Batch Fabrication of Microscale Gear-Like Tissue by Alginate-Poly-L-lysine (PLL) Microcapsules System

Zeyang Liu, Masaru Takeuchi, Masahiro Nakajima, Toshio Fukuda, Yasuhisa Hasegawa, Qiang Huang
RA-L 2016

Constructing 3D cell module with certain shape and high cell density is a very important issue for artificial tissue engineering. In this letter, we present a novel method of fabricating compact microtissue with gear-like shape by electrodepositing of Ca <sup xmlns:mml="http://www.w3.org/1998/Math/M

Cited by 9Source ↗Scholar ↗
2016

High-Speed Bioassembly of Cellular Microstructures With Force Characterization for Repeating Single-Step Contact Manipulation

Huaping Wang, Qing Shi, Tao Sun, Xiaoming Liu, Masahiro Nakajima, Qiang Huang +2
RA-L 2016

In vitro tissues are significant biological substitute for drug test, cell morphogenesis exploration and organ transplantation. In this letter, a novel microrobotic bioassembly method is proposed to engineer 3-D cellular structure, which can be utilized to culture in vitro tissue with microstructura

Cited by 2Source ↗Scholar ↗
2016

Micromanipulation for Coiling Microfluidic Spun Alginate Microfibers by Magnetically Guided System

Tao Sun, Huaping Wang, Qing Shi, Masaru Takeuchi, Masahiro Nakajima, Qiang Huang +1
RA-L 2016

Alginate hydrogel microfibers are a promising cell-laden module for three-dimensional (3-D) assembly to build cellular structures. However, it is still a challenge to manipulate them for microassembly. In this letter, we report a novel magnetic control method to handle this challenge. To enhance the

Cited by 9Source ↗Scholar ↗
2016

Novel In situ nanomanipulation integrated with SEM-CT imaging system

Masahiro Nakajima, Masaru Takeuchi, Naoki Hisamoto, Toshio Fukuda, Yasuhisa Hasegawa, Qiang Huang
ICRA 2016

This paper presents a novel In situ nanomanipulation integrated with scanning electron microscope- computed tomography (SEM-CT) imaging system for 3D nanomanipulation. In our previous works, a nanorobotic manipulation system was established inside an environmental-SEM (E-SEM) for water-contained sam

Cited by 3Source ↗Scholar ↗
2016

Self-assembly of toroidal magnetic microstructures towards in vitro cell structures

Masaru Takeuchi, Mamoru Hattori, Akihiko Ichikawa, Kenichi Ohara, Masahiro Nakajima, Toshio Fukuda +2
IROS 2016poster

In this paper, we propose a new method to assemble microstructures with biological cells towards in vitro 3D cellular structures. The proposed assembly method uses self-assembly process of magnetized toroidal microstructures. Biocompatible toroidal hydrogel microstructures are prepared by electrodep…

Cited by 7Source ↗Scholar ↗
2015

Electrodeposition of cell-laden alginate-PLL hydrogel structures for spatially selective entrapment

Zeyang Liu, Masaru Takeuchi, Masahiro Nakajima, Toshio Fukuda, Yasuhisa Hasegawa, Qiang Huang
IROS 2015poster

In this study, cell-laden alginate-poly-L-lysine (PLL) hydrogel structures with arbitrary shapes were constructed based on electrodeposition method. Electrolysis of water in alginate solutions with calcium carbonate particles induced alginate gelation on micro-patterned anode electrode, and cell-lad…

Cited by 4Source ↗Scholar ↗
2015

Lab in a Droplet (LiD): Self-assembly of micro-nano structures inside a Droplet using surface tension

Masaru Takeuchi, Akihiko Ichikawa, Masahiro Nakajima, Toshio Fukuda, Yasuhisa Hasegawa, Qiang Huang
ICRA 2015poster

In this paper, we conducted a new method to assemble microstructures inside a droplet named “Lab in a Droplet (LiD)”. The method can realize the assembly of micro-nano structures inside a droplet size. The surface tension is used to assemble microstructures automatically. Micro-scale or nano-scale o…

Cited by 2Source ↗Scholar ↗
2015

Survival microinjection into C. elegans with in vivo observation based on micromanipulation

Masahiro Nakajima, Yuki Ayamura, Masaru Takeuchi, Naoki Hisamoto, Strahil Pastuhov, Yasuhisa Hasegawa +2
IROS 2015poster

This study presents the survival microinjection into Caenorhabditis elegans (C. elegans) with in vivo observation based on micromanipulation. The microinjections were achieved with micro-gel beads which are enable to encapsulate chemicals for injection. In this study, a fluorescent material was used…

Cited by 1Source ↗Scholar ↗
2015

Three-dimensional magnetic assembly of alginate microfibers using microfluidic “printing” method

Tao Sun, Qiang Huang, Qing Shi, Huaping Wang, Masahiro Nakajima, Toshio Fukuda
ICRA 2015poster

Due to the poor controllability in hydrogels, Hydrogels-based assembly to form larger 3D complex shapes is still a big challenge. In this paper, we have reported a novel “bottom-up” method to fabricate three-dimensional (3D) magnetic alginate microfibers (MAMs) assemblies with complex shapes. Specif…

Cited by 2Source ↗Scholar ↗