10 accepted papers
Cell fusion has been widely applied in scientific research for cancer immunotherapy, antibody production, and nuclear reprogramming of somatic cells, and therefore the cell fusion technique that enable us to precisely control the fusion process with high throughput manner has been desired. Here, we…
In single-cell/spheroid analyses, flow cytometry plays a key role in high-throughput measurements. Among the considerable numbers of indexes available for a target evaluation, mechanical characteristics such as a Young's modulus have been focused upon as new indexes related to physiological conditio
Robot integrated microfluidic chip is a key technology for microscale applications. Recently, the technology has been applied to on-chip mixing, which mix solutions on a microfluidic chip because it is a promising tool to analyze not only the chemical reaction with the small sample volume, but also
Robot-integrated microfluidic chip is a promising tool to realize mechanical characterization of a single cell with high throughput and high accuracy. The microfluidic chip used in our system has a pair of mechanical microprobes to measure deformation and reaction force of cells. In our previous stu
An automatic system for evaluating single cell viscoelasticity is proposed and tested in this paper. The system includes three main operations, and they are the operations of catch, load and launch. In the catch operation, the system is capable of capturing a target cell by high-speed vision and hig
Monitoring of biosignals plays important roles in health management in daily life. Especially, the sensing method of biosignals, which does not require special efforts such as restraining people or wearing the sensors to measure them, is really important to maintain monitoring activities of people.…
Cyanobacteria have ion channels which response to osmolarity change in living environment. Since it may lead to the mechanical characteristics changes of the cell itself due to the intracellular pressure changes, we focus on constructing the mechanical characteristics measurement system of Synechocy…
We present a novel cell manipulation method based on vibration-induced flow in open-chip environment. By applying circular vibration to a chip having micropillar patterns on its surface, local whirling flow is induced around the micropillars. Therefore, by patterning micropillar array on a chip and…
This paper proposes the method for mechanical characterization of floating cells on a microfluidic chip. We measured the reactive force of cells on the chip by applying mechanical deformation to the cells. Particularly we focused on the method to improve the sensing resolution of the probe position…
We present a super wide-measurement range load sensor with high-durability for multi-biosignal sensing in daily life. We employed quartz crystal resonator (QCR) load sensor with super wide range (from 6 × 10-5 to 30 [N]) for sensing of biosignals ranging from mN order (e.g. heartbeat) to 100 N order…