102 accepted papers
Linking genomic DNA to quantitative, context-specific expression remains a central challenge in computational biology. Current foundation models capture either tissue context or sequence features, but not both. Cross-omics systems, in turn, often overlook critical mechanisms such as alternative spli…
Image captions serve as efficient surrogates for visual content in multimodal systems such as retrieval, recommendation, multi-step agentic inference pipelines. Yet current evaluation practices miss a fundamental question: Can captions stand-in for images in real downstream tasks? We propose a utili
Vision-language models (VLMs) have achieved remarkable multimodal understanding and reasoning capabilities, yet remain computationally expensive due to dense visual tokenization. Existing efficiency approaches either merge redundant visual tokens or drop them progressively in language backbone, ofte
This paper focuses on enhancing the grasping precision and generalization of manipulation policies learned via imitation learning. Diffusion-based policy learning methods have recently become the mainstream approach for robotic manipulation tasks. As grasping is a critical subtask in manipulation, t
The rapid advancement of text-to-image (T2I) models has increased the need for reliable human preference modeling, a demand further amplified by recent progress in reinforcement learning for preference alignment. However, existing approaches typically quantify the quality of a generated image using…
Multimodal Large Language Models (MLLMs) have achieved notable gains in various tasks by incorporating Chain-of-Thought (CoT) reasoning in language spaces. Recent work extends this direction by leveraging external tools for visual editing, thereby enhancing the visual signal along the reasoning traj…
Recent advances in diffusion-based text-to-video (T2V) models have demonstrated remarkable progress, but these models still face challenges in generating videos with multiple objects. Most models struggle with accurately capturing complex object interactions, often treating some objects as static ba…
Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently designed DNA tokenizers, existing approaches with naive masked
The increasing autonomy of Large Language Models (LLMs) necessitates a rigorous evaluation of their potential to aid in cyber offense. Existing benchmarks often lack real-world complexity and are thus unable to accurately assess LLMs' cybersecurity capabilities. To address this gap, we introduce PAC…
Generating physically stable and novel metal-organic frameworks (MOFs) for inverse design that meet specific performance targets is a significant challenge. Existing generative models often struggle to explore the vast chemical and structural space effectively, leading to suboptimal solutions or mod…
Designing 3D ligands that bind to a given protein pocket with high affinity is a fundamental task in Structure-Based Drug Design (SBDD). However, the lack of synthesizability of 3D ligands has been hindering progress toward experimental validation; moreover, computationally evaluating synthesizabili…
The modeling of genomic sequences presents unique challenges due to their long length and structural complexity. Traditional sequence models struggle to capture long-range dependencies and biological features inherent in DNA. In this work, we propose TrinityDNA, a novel DNA foundational model design
Video agentic models have advanced challenging video-language tasks. However, most agentic approaches still heavily rely on greedy parsing over densely sampled video frames, resulting in high computational cost. We present VideoSeek, a long-horizon video agent that leverages video logic flow to acti
Omni-modal large language models (OLLMs) aim to unify audio, vision, and text understanding within a single framework. While existing benchmarks have advanced multimodal evaluation, it remains unclear whether OLLMs achieve modality-invariant reasoning or inherit modality-specific biases. We introduc…
Humans express uncertainty verbally via markers (e.g., "possible", "likely"), yet most LLM uncertainty quantification (UQ) relies on costing likelihood- or consistency-based signals. From a cognitive perspective, accurate verbal uncertainty reflects metacognitive monitoring, representing knowledge b…
Historically, scientific discovery has been a lengthy and costly process, demanding substantial time and resources from initial conception to final results. To accelerate scientific discovery, reduce research costs, and improve research quality, we introduce Agent Laboratory, an autonomous LLM-based
Recently, Vision Large Language Models (VLLMs) with integrated vision encoders have shown promising performance in vision understanding. They encode visual content into sequences of visual tokens, enabling joint processing of visual and textual data. However, understanding videos, especially long vi…
Accurate protein identification from mass spectrometry (MS) data is fundamental to unraveling the complex roles of proteins in biological systems, with peptide sequencing being a pivotal step in this process. The two main paradigms for peptide sequencing are database search, which matches experiment…
Structure-based drug design (SBDD) aims to generate potential drugs that can bind to a target protein and is greatly expedited by the aid of AI techniques in generative models. However, a lack of systematic understanding persists due to the diverse settings, complex implementation, difficult reprodu…
Score Distillation Sampling (SDS) has been successfully extended to text-driven 3D scene editing with 2D pretrained diffusion models. However, SDS-based editing methods suffer from lengthy optimization processes with slow inference and low quality. We attribute the issue of lengthy optimization to t…
Motif-scaffolding is a fundamental component of protein design, which aims to construct the scaffold structure that stabilizes motifs conferring desired functions. Recent advances in generative models are promising for designing scaffolds, with two main approaches: training-based and sampling-based…
In this paper, we empirically demonstrate that natural images can be reconstructed with high fidelity from compressed representations using a simple first-order norm-plus-linear autoregressive (FINOLA) process—without relying on explicit positional information. Through systematic analysis, we observ…
Recent advances in latent diffusion models have demonstrated their effectiveness for high-resolution image synthesis. However, the properties of the latent space from tokenizer for better learning and generation of diffusion models remain under-explored. Theoretically and empirically, we find that i…
Masked Image Modeling (MIM) with Vector Quantization (VQ) has achieved great success in both self-supervised pre-training and image generation. However, most existing methods struggle to address the trade-off in the shared latent space for generation quality vs. representation learning and efficienc…
Answering complex, long-context questions remains a major challenge for large language models (LLMs) as it requires effective question clarifications and context retrieval. We propose Agentic Long-Context Understanding (AgenticLU), a framework designed to enhance an LLM’s understanding of such queri…
Efficient image tokenization with high compression ratios remains a critical challenge for training generative models.We present SoftVQ-VAE, a continuous image tokenizer that leverages soft categorical posteriors to aggregate multiple codewords into each latent token, substantially increasing the re…
Large reasoning models (LRMs) have demonstrated impressive reasoning capabilities across a broad range of tasks including Olympiad-level mathematical problems, indicating evidence of their complex reasoning abilities. While many reasoning benchmarks focus on the STEM domain, the ability of LRMs to r
Training large language models (LLMs) poses challenges due to their massive scale and heterogeneous architectures. While adaptive optimizers like AdamW help address gradient variations, they still struggle with efficient and effective parameter-wise learning rate estimation, resulting in training in…
Recent advancements in timestep-distilled diffusion models have enabled high-quality image generation that rivals non-distilled multi-step models, but with significantly fewer inference steps. While such models are attractive for applications due to the low inference cost and latency, fine-tuning th…
Recent long-form video-language understanding benchmarks have driven progress in video large multimodal models (Video-LMMs). However, the scarcity of well-annotated long videos has left the training of hour-long Video-LMMs underexplored. To close this gap, we present VideoMarathon, a large-scale hou…
We introduce a Cascaded Diffusion Model (Cas-DM) that improves a Denoising Diffusion Probabilistic Model (DDPM) by effectively incorporating additional metric functions in training. Metric functions such as the LPIPS loss have been proven highly effective in consistency models derived from the score…
This paper presents a novel approach to object completion, with the primary goal of reconstructing a complete object from its partially visible components. Our method, named MaskComp, delineates the completion process through iterative stages of generation and segmentation. In each iteration, the ob…
Generative AI has made significant strides in computer vision particularly in text-driven image/video synthesis (T2I/T2V). Despite the notable advancements it remains challenging in human-centric content synthesis such as realistic dance generation. Current methodologies primarily tailored for human…
"This paper presents a Generative RegIon-to-Text transformer, GRiT, for object understanding. The spirit of GRiT is to formulate object understanding as
"Significant advances have been made in human-centric video generation, yet the joint video-depth generation problem remains underexplored. Most existing monocular depth estimation methods may not generalize well to synthesized images or videos, and multi-view-based methods have difficulty controlli…
"We introduce “Idea to Image,”1 an agent system that enables multimodal iterative self-refinement with for automatic image design and generation. Humans can quickly identify the characteristics of different text-to-image (T2I) models via iterative explorations. This enables them to efficiently conve…
Transformer models have been successful in various sequence processing tasks, but the self-attention mechanism's computational cost limits its practicality for long sequences. Although there are existing attention variants that improve computational efficiency, they have a limited ability to abstrac…
We present MM-Narrator a novel system leveraging GPT-4 with multimodal in-context learning for the generation of audio descriptions (AD). Unlike previous methods that primarily focused on downstream fine-tuning with short video clips MM-Narrator excels in generating precise audio descriptions for vi…
We propose MM-Vet, an evaluation benchmark that examines large multimodal models (LMMs) on complicated multimodal tasks. Recent LMMs have shown various intriguing abilities, such as solving math problems written on the blackboard, reasoning about events and celebrities in news images, and explaining…
By contextualizing the kernel as global as possible, Modern ConvNets have shown great potential in computer vision tasks. However, recent progress on \textit{multi-order game-theoretic interaction} within deep neural networks (DNNs) reveals the representation bottleneck of modern ConvNets, where the…
Avoiding synthesizing specific visual concepts is an essential challenge in responsible visual synthesis. However, the visual concept that needs to be avoided for responsible visual synthesis tends to be diverse, depending on the region, context, and usage scenarios. In this work, we formalize a new…
Therapeutic peptides have proven to have great pharmaceutical value and potential in recent decades. However, methods of AI-assisted peptide drug discovery are not fully explored. To fill the gap, we propose a target-aware peptide design method called PPFlow, based on conditional flow matching on to…
Compound-Protein Interaction (CPI) prediction aims to predict the pattern and strength of compound-protein interactions for rational drug discovery. Existing deep learning-based methods utilize only the single modality of protein sequences or structures and lack the co-modeling of the joint distribu…
While artificial intelligence has made remarkable strides in revealing the relationship between biological macromolecules' primary sequence and tertiary structure, designing RNA sequences based on specified tertiary structures remains challenging. Though existing approaches in protein design have th…
We propose a method to efficiently equip the Segment Anything Model (SAM) with the ability to generate regional captions. SAM presents strong generalizability to segment anything while is short for semantic understanding. By introducing a lightweight query-based feature mixer we align the region-spe…
Semi-supervised learning (SSL) has witnessed great progress with various improvements in the self-training framework with pseudo labeling. The main challenge is how to distinguish high-quality pseudo labels against the confirmation bias. However, existing pseudo-label selection strategies are limite…
To mitigate the computational complexity in the self-attention mechanism on long sequences, linear attention utilizes computation tricks to achieve linear complexity, while state space models (SSMs) popularize a favourable practice of using non-data-dependent memory pattern, *i.e.,* emphasize the ne…
To leverage LLMs for visual synthesis, traditional methods convert raster image information into discrete grid tokens through specialized visual modules, while disrupting the model’s ability to capture the true semantic representation of visual scenes. This paper posits that an alternative represent…
Diffusion-based image super-resolution (SR) models have attracted substantial interest due to their powerful image restoration capabilities. However, prevailing diffusion models often struggle to strike an optimal balance between efficiency and performance. Typically, they either neglect to exploit…
Diffusion models have demonstrated unprecedented capabilities in image generation. Yet they incorporate and amplify the data bias (e.g. gender age) from the original training set limiting the diversity of generated images. In this paper we propose a diversity-oriented fine-tuning method using reinfo…
Similar to natural language models, pre-trained genome language models are proposed to capture the underlying intricacies within genomes with unsupervised sequence modeling. They have become essential tools for researchers and practitioners in biology. However, the hand-crafted tokenization policies…
The most recent efforts in video matting have focused on eliminating trimap dependency since trimap annotations are expensive and trimap-based methods are less adaptable for real-time applications. Despite the latest tripmap-free methods showing promising results, their performance often degrades wh…
Masked visual modeling (MVM) has been recently proven effective for visual pre-training. While similar reconstructive objectives on video inputs (e.g., masked frame modeling) have been explored in video-language (VidL) pre-training, previous studies fail to find a truly effective MVM strategy that c…
In this paper, we show that a binary latent space can be explored for compact yet expressive image representations. We model the bi-directional mappings between an image and the corresponding latent binary representation by training an auto-encoder with a Bernoulli encoding distribution. On the one…
Improving the generalization ability of Deep Neural Networks (DNNs) is critical for their practical uses, which has been a longstanding challenge. Some theoretical studies have uncovered that DNNs have preferences for some frequency components in the learning process and indicated that this may affe…
Motivated by the fact that forward and backward passes of a deep network naturally form symmetric mappings between input and output representations, we introduce a simple yet effective self-supervised vision model pretraining framework inspired by energy-based models (EBMs). In the proposed framewor…
This study explores the concept of equivariance in vision-language foundation models (VLMs), focusing specifically on the multimodal similarity function that is not only the major training objective but also the core delivery to support downstream tasks. Unlike the existing image-text similarity obj…
Mixup is an efficient data augmentation approach that improves the generalization of neural networks by smoothing the decision boundary with mixed data. Recently, dynamic mixup methods have improved previous \textit{static} policies effectively (e.g., linear interpolation) by maximizing target-relat…
Unified vision-language frameworks have greatly advanced in recent years, most of which adopt an encoder-decoder architecture to unify image-text tasks as sequence-to-sequence generation. However, existing video-language (VidL) models still require task-specific designs in model architecture and tra…
Recently, both Contrastive Learning (CL) and Mask Image Modeling (MIM) demonstrate that self-supervision is powerful to learn good representations. However, naively combining them is far from success. In this paper, we start by making the empirical observation that a naive joint optimization of CL a…
3D photography renders a static image into a video with appealing 3D visual effects. Existing approaches typically first conduct monocular depth estimation, then render the input frame to subsequent frames with various viewpoints, and finally use an inpainting model to fill those missing/occluded re…
In this paper, we propose NUWA-XL, a novel Diffusion over Diffusion architecture for eXtremely Long video generation. Most current work generates long videos segment by segment sequentially, which normally leads to the gap between training on short videos and inferring long videos, and the sequentia…
We present a unified framework for camera-space 3D hand pose estimation from a single RGB image based on 3D implicit representation. As opposed to recent works, most of which first adopt holistic or pixel-level dense regression to obtain relative 3D hand pose and then follow with complex second-stag…
Spatio-temporal predictive learning is a learning paradigm that enables models to learn spatial and temporal patterns by predicting future frames from given past frames in an unsupervised manner. Despite remarkable progress in recent years, a lack of systematic understanding persists due to the dive…
The paper introduces PaintSeg, a new unsupervised method for segmenting objects without any training. We propose an adversarial masked contrastive painting (AMCP) process, which creates a contrast between the original image and a painted image in which a masked area is painted using off-the-shelf ge…
Recently, large-scale text-to-image (T2I) models have shown impressive performance in generating high-fidelity images, but with limited controllability, e.g., precisely specifying the content in a specific region with a free-form text description. In this paper, we propose an effective technique for…
"Current object detection systems and benchmarks typically handle a limited number of categories, up to about a thousand categories. This paper scales the number of categories for object detection systems and benchmarks up to 21,000, by leveraging existing object detection and image classification d…
Knowledge-based visual question answering (VQA) involves answering questions that require external knowledge not present in the image. Existing methods first retrieve knowledge from external resources, then reason over the selected knowledge, the input image, and question for answer prediction. Howe…
Vision-and-language (VL) pre-training has proven to be highly effective on various VL downstream tasks. While recent work has shown that fully transformer-based VL models can be more efficient than previous region-feature-based methods, their performance on downstream tasks often degrades significan…
Inversion techniques are widely used to reconstruct subsurface physical properties (e.g., velocity, conductivity) from surface-based geophysical measurements (e.g., seismic, electric/magnetic (EM) data). The problems are governed by partial differential equations (PDEs) like the wave or Maxwell’s eq…
"Data mixing augmentation have proved to be effective for improving the generalization ability of deep neural networks. While early methods mix samples by hand-crafted policies (\textit{e.g.}, linear interpolation), recent methods utilize saliency information to match the mixed samples and labels vi…
Vision-language (VL) pre-training has recently received considerable attention. However, most existing end-to-end pre-training approaches either only aim to tackle VL tasks such as image-text retrieval, visual question answering (VQA) and image captioning that test high-level understanding of images…
We present a cross-modal Transformer-based framework, which jointly encodes video data and text labels for zero-shot action recognition (ZSAR). Our model employs a conceptually new pipeline by which visual representations are learned in conjunction with visual-semantic associations in an end-to-end…
Learning visual representations from natural language supervision has recently shown great promise in a number of pioneering works. In general, these language-augmented visual models demonstrate strong transferability to a variety of datasets/tasks. However, it remains challenging to evaluate the tr…
Tremendous progress has been made in recent years in developing better image captioning models, yet most of them rely on a separate object detector to extract regional features. Recent vision-language studies are shifting towards the detector-free trend by leveraging grid representations for more fl…
Unsupervised domain adaptive person re-identification (ReID) has been extensively investigated to mitigate the adverse effects of domain gaps. Those works assume the target domain data can be accessible all at once. However, for the real-world streaming data, this hinders the timely adaptation to ch…
We present Mobile-Former, a parallel design of MobileNet and transformer with a two-way bridge in between. This structure leverages the advantages of MobileNet at local processing and transformer at global interaction. And the bridge enables bidirectional fusion of local and global features. Differe…
Infinite visual synthesis aims to generate high-resolution images, long-duration videos, and even visual generation of infinite size. Some recent work tried to solve this task by first dividing data into processable patches and then training the models on them without considering the dependencies be…
We introduce the task of open-vocabulary visual instance search (OVIS). Given an arbitrary textual search query, Open-vocabulary Visual Instance Search (OVIS) aims to return a ranked list of visual instances, i.e., image patches, that satisfies the search intent from an image database. The term ``op…
Large-scale pre-training has recently revolutionized vision-and-language (VL) research. Models such as LXMERT and UNITER have significantly lifted the state of the art over a wide range of VL tasks. However, the large number of parameters in such models hinders their application in practice. In para…
In recent years, we have witnessed significant performance boost in the image captioning task based on vision-language pre-training (VLP). Scale is believed to be an important factor for this advance. However, most existing work only focuses on pre-training transformers with moderate sizes (e.g., 12…
"The complexity-precision trade-off of an object detector is a critical problem for resource constrained vision tasks. Previous works have emphasized detectors implemented with efficient backbones. The impact on this trade-off of proposal processing by the detection head is investigated in this work…
The canonical approach to video captioning dictates a caption generation model to learn from offline-extracted dense video features. These feature extractors usually operate on video frames sampled at a fixed frame rate and are often trained on image/video understanding tasks, without adaption to vi…
It has become cognitive inertia to employ cross-entropy loss function in classification related tasks. In the untargeted attacks on graph structure, the gradients derived from the attack objective are the attacker's basis for evaluating a perturbation scheme. Previous methods use negative cross-entr…
"We propose UniTAB that Unifies Text And Box outputs for grounded vision-language (VL) modeling. Grounded VL tasks such as grounded captioning require the model to generate a text description and align predicted words with object regions. To achieve this, models must generate desired text and box ou…
This paper investigates unsupervised learning of Full-Waveform Inversion (FWI), which has been widely used in geophysics to estimate subsurface velocity maps from seismic data. This problem is mathematically formulated by a second order partial differential equation (PDE), but is hard to solve. More…
Despite exciting progress in pre-training for visual-linguistic (VL) representations, very few aspire to a small VL model. In this paper, we study knowledge distillation(KD) to effectively compress a transformer-based large VL model into a small VL model. The major challenge arises from the inconsis…
We present a new method, called MEsh TRansfOrmer (METRO), to reconstruct 3D human pose and mesh vertices from a single image. Our method uses a transformer encoder to jointly model vertex-vertex and vertex-joint interactions, and outputs 3D joint coordinates and mesh vertices simultaneously. Compare…
Previous pseudo-label approaches for semi-supervised object detection typically follow a multi-stage schema, with the first stage to train an initial detector on a few labeled data, followed by the pseudo labeling and re-training stage on unlabeled data. These multi-stage methods complicate the trai…
We present a graph-convolution-reinforced transformer, named Mesh Graphormer, for 3D human pose and mesh reconstruction from a single image. Recently both transformers and graph convolutional neural networks (GCNNs) have shown promising progress in human mesh reconstruction. Transformer-based approa…
This paper aims at addressing the problem of substantial performance degradation at extremely low computational cost (e.g. 5M FLOPs on ImageNet classification). We found that two factors, sparse connectivity and dynamic activation function, are effective to improve the accuracy. The former avoids th…
Semantic correspondence is a fundamental problem in computer vision, which aims at establishing dense correspondences across images depicting different instances under the same category. This task is challenging due to large intra-class variations and a severe lack of ground truth. A popular solutio…
Recent research in dynamic convolution shows substantial performance boost for efficient CNNs, due to the adaptive aggregation of K static convolution kernels. It has two limitations: (a) it increases the number of convolutional weights by K-times, and (b) the joint optimization of dynamic attention…
This paper is concerned with self-supervised learning for small models. The problem is motivated by our empirical studies that while the widely used contrastive self-supervised learning method has shown great progress on large model training, it does not work well for small models. To address this p…
Neural Architecture Search (NAS) often trains and evaluates a large number of architectures. Recent predictor-based NAS approaches attempt to alleviate such heavy computation costs with two key steps: sampling some architecture-performance pairs and fitting a proxy accuracy predictor. Given limited…
Most existing video-and-language (VidL) research focuses on a single dataset, or multiple datasets of a single task. In reality, a truly useful VidL system is expected to be easily generalizable to diverse tasks, domains, and datasets. To facilitate the evaluation of such systems, we introduce Video…
It is highly desirable yet challenging to generate image captions that can describe novel objects which are unseen in caption-labeled training data, a capability that is evaluated in the novel object captioning challenge (nocaps). In this challenge, no additional image-caption training data, other t…
Light-weight convolutional neural networks (CNNs) suffer performance degradation as their low computational budgets constrain both the depth (number of convolution layers) and the width (number of channels) of CNNs, resulting in limited representation capability. To address this issue, we present Dy…
Rectified linear units (ReLU) are commonly used in deep neural networks. So far ReLU and its generalizations (non-parametric or parametric) are static, performing identically for all input samples. In this paper, we propose dynamic ReLU (DY-ReLU), a dynamic rectifier of which parameters are generate…
Two head structures (i.e. fully connected head and convolution head) have been widely used in R-CNN based detectors for classification and localization tasks. However, there is a lack of understanding of how does these two head structures work for these two tasks. To address this issue, we perform a…
Modern machine learning suffers from catastrophic forgetting when learning new classes incrementally. The performance dramatically degrades due to the missing data of old classes. Incremental learning methods have been proposed to retain the knowledge acquired from the old classes, by using knowledg…
We address the problem of person re-identification from commodity depth sensors. One challenge for depth-based recognition is data scarcity. Our first contribution addresses this problem by introducing split-rate RGB-to-Depth transfer, which leverages large RGB datasets more effectively than popular…