19 accepted papers
Predicting single-cell perturbation outcomes directly advances gene function analysis and facilitates drug candidate selection, making it a key driver of both basic and translational biomedical research. However, a major bottleneck in this task is the unpaired nature of single-cell data, as the same
Autonomous vehicles operating in open-world environments must continually adapt to rare long-tail scenarios while preserving previously acquired driving skills. However, existing trajectory planning approaches struggle with this stability-plasticity trade-off, as they rely on static models or rigid …
Identifying T-cell receptors (TCRs) that interact with antigenic peptides provides the technical basis for developing vaccines and immunotherapies. The emergent deep learning methods excel at learning antigen binding patterns from known TCRs but struggle with novel or sparsely represented antigens.…
Computational protein design (CPD) offers transformative potential for bioengineering, but current deep CPD models, focused on universal domains, struggle with function-specific designs. This work introduces a novel CPD paradigm tailored for functional design tasks, particularly for enzymes a key pr…
Tandem mass spectrometry has played a pivotal role in advancing proteomics, enabling the high-throughput analysis of protein composition in biological tissues. Despite the development of several deep learning methods for predicting amino acid sequences (peptides) responsible for generating the obser…
Antibodies are crucial proteins produced by the immune system in response to foreign substances or antigens. The specificity of an antibody is determined by its complementarity-determining regions (CDRs), which are located in the variable domains of the antibody chains and form the antigen-binding s…
The secondary structure of ribonucleic acid (RNA) is more stable and accessible in the cell than its tertiary structure, making it essential for functional prediction. Although deep learning has shown promising results in this field, current methods suffer from poor generalization and high complexit…
Learning effective representations is imperative for comprehending proteins and deciphering their biological functions. Recent strides in language models and graph neural networks have empowered protein models to harness primary or tertiary structure information for representation learning. Neverthe…
By contextualizing the kernel as global as possible, Modern ConvNets have shown great potential in computer vision tasks. However, recent progress on \textit{multi-order game-theoretic interaction} within deep neural networks (DNNs) reveals the representation bottleneck of modern ConvNets, where the…
Protein structure-based property prediction has emerged as a promising approach for various biological tasks, such as protein function prediction and sub-cellular location estimation. The existing methods highly rely on experimental protein structure data and fail in scenarios where these data are u…
Similar to natural language models, pre-trained genome language models are proposed to capture the underlying intricacies within genomes with unsupervised sequence modeling. They have become essential tools for researchers and practitioners in biology. However, the hand-crafted tokenization policies…
Sign language recognition (SLR) is a weakly supervised task that annotates sign videos as textual glosses. Recent studies show that insufficient training caused by the lack of large-scale available sign datasets becomes the main bottleneck for SLR. Most SLR works thereby adopt pretrained visual modu…
This paper proposes a simple yet effective method to re-move shadows from text document images. It mainly includes several parts. Firstly, we propose a text elimination-based background extraction strategy to estimate shadow map. It indicates the shadow regions accurately and helps to predict global…
Molecular Property Prediction (MPP) is a crucial task in the AI-driven Drug Discovery (AIDD) pipeline, which has recently gained considerable attention thanks to advancements in deep learning. However, recent research has revealed that deep models struggle to beat traditional non-deep ones on MPP. I…
Dropout has emerged as one of the most frequently used techniques for training deep neural networks (DNNs). Although effective, the sampled sub-model by random dropout during training is inconsistent with the full model (without dropout) during inference. To mitigate this undesirable gap, we propose…
Although contextualized embeddings generated from large-scale pre-trained models perform well in many tasks, traditional static embeddings (e.g., Skip-gram, Word2Vec) still play an important role in low-resource and lightweight settings due to their low computational cost, ease of deployment, and st…
Research on document-level Neural Machine Translation (NMT) models has attracted increasing attention in recent years. Although the proposed works have proved that the inter-sentence information is helpful for improving the performance of the NMT models, what information should be regarded as contex…
In this paper we present a novel approach for depth map enhancement from an RGB-D video sequence. The basic idea is to exploit the photometric information in the color sequence. Instead of making any assumption about surface albedo or controlled object motion and lighting, we use the lighting variat…
In this paper we present a method of using standard multi-view images for 3D surface reconstruction of non-Lambertian objects. We extend the original visual hull concept to incorporate 3D cues presented by internal occluding contours, i.e., occluding contours that are inside the object's silhouettes…