8 accepted papers
Physical parameters of the intracellular environment such as mass density, intracellular pressure and elasticity have significant effects on the physiological activities of the cell and intracellular operation results. However, the significantly different measurement principles of the above paramete
The inside-out patch clamp technique has been widely applied in brain science and neuroscience research due to its ability to detect extremely weak currents flowing through a single ion channel. The current manual inside-out patch clamp operations are highly expertise-requisite and low efficient. Me
Cell rotation is widely used to adjust cell posture in sub-cellular micromanipulations. The trajectory planning of the injection micropipette is needed, so that the cells can be rotated with the minimum deformation to reduce cell damage and keep cell viability. Due to the uncertainty of cell propert…
Cell rotation has great significance for cell manipulation, which is applied to intracytoplasmic sperm injection, preimplantation genetic screening and diagnosis, somatic cell nuclear transfer, etc. In this letter, an automatic cell rotation method is proposed based on real-time detection and tracki
Robotic manipulation of deformable objects (vs. rigid objects) has been a classic topic in robotics. Compared to deformable synthetic objects such as rubber balls and clothes, biological cells are highly deformable and more prone to damage. This paper presents robotic manipulation of deformable cell…
Magnetic micromanipulation is an untethered technique and has enabled numerous applications in the scale of millimeters to micrometers from the tissue level to cell level. However, existing systems are not capable of maneuvering a sub-micrometer object for precise force control, preventing the reali…
Cell morphology plays an important role in maintaining normal cellular functions. Existing techniques for cell morphology measurement, such as confocal imaging and atomic force microscopy, have the limitations of photobleaching and incompatibility for integration with other cell manipulation instrum
Embryo vitrification is an essential cryopreservation technique in IVF (in vitro fertilization) clinics. Vitrification involves pick-and-place of an embryo in multiple types of cryoprotectant solutions for processing before placing the embryo on a vitrification straw for cryopreservation in liquid n