115 accepted papers
Large language models (LLMs) have shown strong potential in automating the design of agentic workflows. However, existing methods still rely heavily on manually predefined operators, limiting generalization and scalability. To address this issue, we propose A²Flow, a fully automated framework for ag
Multi-domain reinforcement learning (RL) for large language models (LLMs) involves highly intricate reward surfaces, posing significant challenges in finding parameters that excel across all domains. Recent empirical studies have further highlighted conflicts among domains, where gains in one capabi…
Recent releases such as o3 highlight human-like "thinking with images" reasoning that combines tool use with stepwise verification, yet most open-source approaches still rely on text-only chains, rigid visual schemas, or single-step pipelines, limiting flexibility, interpretability, and transferabil
A reliable reward model is essential for aligning large language models (LLMs) with human preferences through reinforcement learning from human feedback (RLHF). However, standard reward models are susceptible to spurious features that are not causally related to human labels. This can lead to *rewar…
Large language models (LLMs), such as OpenAI-o1 and DeepSeek-R1, excel in contextual reasoning by leveraging extensive world knowledge and deep contextual understanding. However, their high computational costs limit deployment in resource-constrained settings. Conversely, small language models (SLMs…
Large Language Models (LLMs) have demonstrated remarkable capabilities in complex reasoning tasks, but their high computational costs limit their widespread practical application. We argue that this inefficiency arises from the tight coupling of high-level cognitive planning (devising the solution s…
We present MIRA (Multimodal Interventional RAdiology evaluation), a comprehensive benchmark for evaluating large multimodal models in expert-level interventional radiology tasks requiring specialized domain knowledge and advanced visual reasoning capabilities. Unlike existing medical benchmarks that
Motion blur arises when rapid scene changes occur during the exposure period, collapsing rich intra-exposure motion into a single RGB frame. Without explicit structural or temporal cues, RGB-only deblurring is highly ill-posed and often fails under extreme motion. Inspired by the human visual system
Nucleus detection in histopathology whole slide images (WSIs) is crucial for a broad spectrum of clinical applications. The gigapixel size of WSIs necessitates the use of sliding window methodology for nucleus detection. However, mainstream methods process each sliding window independently, which ov
While modeling multi-contact manipulation as a quasi-static mechanical process transitioning between different contact equilibria, we propose formulating it as a planning and optimization problem, explicitly evaluating (i) contact stability and (ii) robustness to sensor noise. Specifically, we condu
Recurrent Neural Networks (RNNs) are widely used in control system due to their dynamic capabilities. However, the control accuracy of RNN-based systems can be compromised by noise interference, and there has been little research on RNN-based control in disturbed multi-agent systems. To address this…
The multi-domain fine-tuning of large language models (LLMs) confronts a notorious trade-off among abilities across domains. Existing studies attribute this trade-off to the conflicts between samples rooted in inherent semantics. Recent approaches attempt to mitigate these conflicts through the empi…
Low-rank optimization has emerged as a promising approach to enabling memory-efficient training of large language models (LLMs). Existing low-rank optimization methods typically project gradients onto a low-rank subspace, reducing the memory cost of storing optimizer states. A key challenge in these…
The emergence of large multimodal models (LMMs) has brought significant advancements to pathology. Previous research has primarily focused on separately training patch-level and whole-slide image (WSI)-level models, limiting the integration of learned knowledge across patches and WSIs and resulting…
Recent advances in computational pathology have led to the emergence of numerous foundation models. These models typically rely on general-purpose encoders with multi-instance learning for whole slide image (WSI) classification or apply multimodal approaches to generate reports directly from images.…
We introduce and study the Combinatorial Ski Rental (CSR) problem, which involves multiple items that can be rented or purchased, either individually or in combination. At each time step, a decision-maker must make an irrevocable buy-or-rent decision for items that have not yet been purchased, witho…
We study deployment-efficient reward-free exploration with linear function approximation, where the goal is to explore a linear Markov Decision Process (MDP) without revealing the reward function, while minimizing the number of distinct policies implemented during learning. By ``deployment efficient…
We study the distributed multi-agent multi-armed bandit problem with heterogeneous rewards over random communication graphs. Uniquely, at each time step $t$ agents communicate over a time-varying random graph $\mathcal{G}\_t$ generated by applying the Erdős–Rényi model to a fixed connected base grap…
In this work, we study the federated multi-armed bandit (FMAB) problem, where a set of distributed agents collaboratively aim to minimize cumulative regret while interacting with a shared set of arms. Unlike traditional centralized bandit models, agents in FMAB settings are connected via a communica…
The exploration \& exploitation dilemma poses significant challenges in reinforcement learning (RL). Recently, curiosity-based exploration methods achieved great success in tackling hard-exploration problems. However, they necessitate extensive hyperparameter tuning on different environments, which…
Intrusion detection systems (IDSs) are essential in Intelligent transportation system (ITS) for detecting and identifying malicious activities. Although deep learning is commonly used in IDS, its limited interpretability hinders large-scale deployment. Additionally, the computational and storage con…
Artificial intelligence (AI) shows great potential in assisting radiologists to improve the efficiency and accuracy of medical image interpretation and diagnosis. However, a versatile AI model requires large-scale data and comprehensive annotations, which are often impractical in medical settings. R…
Despite their remarkable performance on various tasks, Large Language Models (LLMs) still struggle with logical reasoning, particularly in complex and multi-step reasoning processes. Among various efforts to enhance LLMs' reasoning capabilities, synthesizing large-scale, high-quality logical reason…
The recent work by Dong and Yang (2023) showed for misspecified sparse linear bandits, one can obtain an $O(\epsilon)$-optimal policy using a polynomial number of samples when the sparsity is a constant, where $\epsilon$ is the misspecification error. This result is in sharp contrast to misspecified…
In this paper, we focus on the research of federated multi-armed bandit (FMAB) problems where agents can only communicate with their neighbors. All agents aim to solve a common multi-armed bandit (MAB) problem to minimize individual regrets, while group regret can also be minimized. In a federated b
Safety is a fundamental challenge in reinforcement learning (RL), particularly in real-world applications such as autonomous driving, robotics, and healthcare. To address this, Constrained Markov Decision Processes (CMDPs) are commonly used to enforce safety constraints while optimizing performance.…
Vision Language Models (VLMs) like CLIP have attracted substantial attention in pathology, serving as backbones for applications such as zero-shot image classification and Whole Slide Image (WSI) analysis. Additionally, they can function as vision encoders when combined with large language models (L…
Pathology whole slide image (WSI) analysis is vital for disease diagnosis and understanding. While foundation models (FMs) have driven recent advances, their scalability in pathology remains a key challenge. In particular, vision-language (VL) pathology FMs align visual features with language annota…
Contact-rich manipulation often requires strategic interactions with objects, such as pushing to accomplish specific tasks. We propose a novel scenario where a robot inserts a book into a crowded shelf by pushing aside neighboring books to create space before slotting the new book into place. Classi
This paper investigates *list replicability* [Dixon et al., 2023] in the context of multi-armed (also linear) bandits (MAB). We define an algorithm $A$ for MAB to be $(\ell,\delta)$-list replicable if with probability at least $1-\delta$, $A$ has at most $\ell$ traces in independent executions even…
While vision language models (VLMs) excel in 2D semantic visual understanding, their ability to quantitatively reason about 3D spatial relationships remains underexplored due to the deficiency of spatial representation ability of 2D images. In this paper, we analyze the problem hindering VLMs’ spat…
Deep learning-based models have achieved impressive performance on public segmentation benchmarks, yet generalizing to unseen environments remains challenging. Test-time training (TTT) addresses this by adapting source-pretrained models during evaluation. While existing TTT methods have shown promis…
Reinforcement learning (RL) often relies on manually designed reward functions, which are difficult to specify and can lead to issues such as reward hacking and suboptimal behavior. Alternatives like inverse RL and preference-based RL attempt to infer surrogate rewards from demonstrations or prefere…
To bridge the gap between empirical success and theoretical understanding in transfer reinforcement learning (RL), we study a principled approach with provable performance guarantees. We introduce a novel composite MDP framework where high-dimensional transition dynamics are modeled as the sum of a…
Diffusion Transformers (DiTs) have recently demonstrated remarkable performance in visual generation tasks, surpassing traditional U-Net-based diffusion models by significantly improving image and video generation quality and scalability. However, the large model size and iterative denoising process…
The constrained Markov decision process (CMDP) framework emerges as an important reinforcement learning approach for imposing safety or other critical objectives while maximizing cumulative reward. However, the current understanding of how to learn efficiently in a CMDP environment with a potentiall…
Point-based cell detection (PCD), which pursues high-performance cell sensing under low-cost data annotation, has garnered increased attention in computational pathology community. Unlike mainstream PCD methods that rely on intermediate density map representations, the Point-to-Point network (P2PNet…
Fine-grained visual classification (FGVC) intends to confirm the sub-classes of a specific object category, e.g., identifying the species of dogs or birds. It is a challenging problem with the inter-class similarity among these sub-categories and intra-class variance in every fine-grained class. Mos…
When humans and robots work together to accomplish tasks with dynamic uncertainty, the robots should perceive human motion intentions so as to cooperate with humans and increase efficacy. In this study, we propose a hierarchical motion intention prediction model for human-robot collaboration, in whi
To tackle long planning horizon problems in reinforcement learning with general function approximation, we propose the first algorithm, termed as UCRL-WVTR, that achieves both \emph{horizon-free} and \emph{instance-dependent}, since it eliminates the polynomial dependency on the planning horizon. Th…
With the booming of Large Language Models (LLMs), prompt-learning has become a promising method mainly researched in various research areas. Recently, many attempts based on prompt-learning have been made to improve the performance of text classification. However, most of these methods are based on…
Multi-Armed Bandit (MAB) systems are witnessing an upswing in applications within multi-agent distributed environments, leading to the advancement of collaborative MAB algorithms. In such settings, communication between agents executing actions and the primary learner making decisions can hinder the…
The success of reinforcement learning (RL) crucially depends on effective function approximation when dealing with complex ground-truth models. Existing sample-efficient RL algorithms primarily employ three approaches to function approximation: policy-based, value-based, and model-based methods. How…
As advances in large language models (LLMs) and multimodal techniques continue to mature, the development of general-purpose multimodal large language models (MLLMs) has surged, offering significant applications in interpreting natural images. However, the field of pathology has largely remained unt…
Histopathology Whole Slide Image (WSI) analysis serves as the gold standard for clinical cancer diagnosis in the daily routines of doctors. To develop computer-aided diagnosis model for histopathology WSIs, previous methods typically employ Multi-Instance Learning to enable slide-level prediction gi…
In this work, we present a simplified quasi-static model of a two-point contact gripper turning a circular valve to predict the reaction torques produced at the base of the valve as a function of the axis misalignment. Specifically, we learned that geometric features such as (i) the misalignment vec…
Existing metrics for reinforcement learning (RL) such as regret, PAC bounds, or uniform-PAC (Dann et al., 2017), typically evaluate the cumulative performance, while allowing the play of an arbitrarily bad policy at any finite time t. Such a behavior can be highly detrimental in high-stakes applicat…
Cooperative multi-agent multi-armed bandits (CM2AB) study how distributed agents cooperatively play the same multi-armed bandit game. Most existing CM2AB works focused on maximizing the group performance of all agents---the accumulation of all agents' individual performance (i.e., individual reward)…
With the advancement of deep learning, computer-assisted clinical diagnosis, such as liquid-based cervical cytology, has attracted more attention. However, the fragile robustness of deep learning models has a non-negligible impact on their classification accuracy and reliability. To be more specific…
We study distributed contextual linear bandits with stochastic contexts, where $N$ agents/learners act cooperatively to solve a linear bandit-optimization problem with $d$-dimensional features over the course of $T$ rounds. For this problem, we derive the first ever information-theoretic lower bound…
Recently, the study of linear misspecified bandits has generated intriguing implications of the hardness of learning in bandits and reinforcement learning (RL). In particular, Du et al. (2020) shows that even if a learner is given linear features in $\mathbb{R}^d$ that approximate the rewards in a b…
In this paper, we provide the first efficient batched algorithm for contextual linear bandits with large action spaces. Unlike existing batched algorithms that rely on action elimination, which are not implementable for large action sets, our algorithm only uses a linear optimization oracle over the…
Bayesian Optimization (BO) is a sample-efficient optimization algorithm widely employed across various applications. In some challenging BO tasks, input uncertainty arises due to the inevitable randomness in the optimization process, such as machining errors, execution noise, or contextual variabili…
This paper studies a cooperative multi-agent bandit scenario in which the rewards observed by agents are heterogeneous—one agent’s meat can be another agent’s poison. Specifically, the total reward observed by each agent is the sum of two values: an arm-specific reward, capturing the intrinsic value…
Horizon dependence is an important difference between reinforcement learning and other machine learning paradigms. Yet, existing results tackling the (exact) horizon dependence either assume that the reward is bounded per step, introducing unfair comparison, or assume strict total boundedness that r…
Policy optimization methods are powerful algorithms in Reinforcement Learning (RL) for their flexibility to deal with policy parameterization and ability to handle model misspecification. However, these methods usually suffer from slow convergence rates and poor sample complexity. Hence it is import…
Large-scale language models have shown the ability to adapt to a new task via conditioning on a few demonstrations (i.e., in-context learning). However, in the vision-language domain, most large-scale pre-trained vision-language (VL) models do not possess the ability to conduct in-context learning.…
This paper studies a cooperative multi-agent multi-armed stochastic bandit problem where agents operate asynchronously – agent pull times and rates are unknown, irregular, and heterogeneous – and face the same instance of a K-armed bandit problem. Agents can share reward information to speed up the…
We theoretically study lifelong reinforcement learning (RL) with linear representation in a regret minimization setting. The goal of the agent is to learn a multi-task policy based on a linear representation while solving a sequence of tasks that may be adaptively chosen based on the agent's past be…
We initiate the mathematical study of replicability as an algorithmic property in the context of reinforcement learning (RL). We focus on the fundamental setting of discounted tabular MDPs with access to a generative model. Inspired by Impagliazzo et al. [2022], we say that an RL algorithm is…
While numerous works have focused on devising efficient algorithms for reinforcement learning (RL) with uniformly bounded rewards, it remains an open question whether sample or time-efficient algorithms for RL with large state-action space exist when the rewards are \emph{heavy-tailed}, i.e., with o…
While Multiple Instance Learning (MIL) has shown promising results in digital Pathology Whole Slide Image (WSI) analysis, such a paradigm still faces performance and generalization problems due to high computational costs and limited supervision of Gigapixel WSIs. To deal with the computation proble…
We study the semi-supervised learning problem, using a few labeled data and a large amount of unlabeled data to train the network, by developing a cross-patch dense contrastive learning framework, to segment cellular nuclei in histopathologic images. This task is motivated by the expensive burden on…
Image-based survival prediction models can facilitate doctors in diagnosing and treating cancer patients. With the advance of digital pathology technologies, the big whole slide images (WSIs) provide increasing resolution and more details for diagnosis. However, the gigabyte-size WSIs would make mos…
For the problem of task-agnostic reinforcement learning (RL), an agent first collects samples from an unknown environment without the supervision of reward signals, then is revealed with a reward and is asked to compute a corresponding near-optimal policy. Existing approaches mainly concern the wors…
Emotion recognition in conversation (ERC) aims to detect the emotion label for each utterance. Motivated by recent studies which have proven that feeding training examples in a meaningful order rather than considering them randomly can boost the performance of models, we propose an ERC-oriented hyb…
Contextual linear bandits is a rich and theoretically important model that has many practical applications. Recently, this setup gained a lot of interest in applications over wireless where communication constraints can be a performance bottleneck, especially when the contexts come from a large $d$-…
Although model-based reinforcement learning (RL) approaches are considered more sample efficient, existing algorithms are usually relying on sophisticated planning algorithm to couple tightly with the model-learning procedure. Hence the learned models may lack the ability of being re-used with more…
In contrast to the advances in characterizing the sample complexity for solving Markov decision processes (MDPs), the optimal statistical complexity for solving constrained MDPs (CMDPs) remains unknown. We resolve this question by providing minimax upper and lower bounds on the sample complexity for…
Multi-agent reinforcement learning (MARL) algorithms often suffer from an exponential sample complexity dependence on the number of agents, a phenomenon known as
An appropriate reward function is of paramount importance in specifying a task in reinforcement learning (RL). Yet, it is known to be extremely challenging in practice to design a correct reward function for even simple tasks. Human-in-the-loop (HiL) RL allows humans to communicate complex goals to…
The multi-armed bandit (MAB) problem is an active learning framework that aims to select the best among a set of actions by sequentially observing rewards. Recently, it has become popular for a number of applications over wireless networks, where communication constraints can form a bottleneck. Exis…
With the development of deep learning, automatic speaker verification has made considerable progress over the past few years. However, to design a lightweight and robust system with limited computational resources is still a challenging problem. Traditionally, a speaker verification system is symmet…
In this paper we consider multi-objective reinforcement learning where the objectives are balanced using preferences. In practice, the preferences are often given in an adversarial manner, e.g., customers can be picky in many applications. We formalize this problem as an episodic learning problem on…
Despite a large amount of effort in dealing with heavy-tailed error in machine learning, little is known when moments of the error can become non-existential: the random noise $\eta$ satisfies Pr$\left[|\eta| > |y|\right] \le 1/|y|^{\alpha}$ for some $\alpha > 0$. We make the first attempt to active…
This paper studies a cooperative multi-armed bandit problem with $M$ agents cooperating together to solve the same instance of a $K$-armed stochastic bandit problem with the goal of maximizing the cumulative reward of agents. The agents are heterogeneous in (i) their limited access to a local subset…
We study the statistical guarantees for the Imitation Learning (IL) problem in episodic MDPs. Rajaraman et al. (2020) show an information theoretic lower bound that in the worst case, a learner which can even actively query the expert policy suffers from a suboptimality growing quadratically in the…
Policy optimization methods remain a powerful workhorse in empirical Reinforcement Learning (RL), with a focus on neural policies that can easily reason over complex and continuous state and/or action spaces. Theoretical understanding of strategic exploration in policy-based methods with non-linear…
This paper presents the first non-asymptotic result showing a model-free algorithm can achieve logarithmic cumulative regret for episodic tabular reinforcement learning if there exists a strictly positive sub-optimality gap. We prove that the optimistic Q-learning studied in [Jin et al. 2018] enjoys…
We propose a model-free reinforcement learning algorithm inspired by the popular randomized least squares value iteration (RLSVI) algorithm as well as the optimism principle. Unlike existing upper-confidence-bound (UCB) based approaches, which are often computationally intractable, our algorithm dri…
Safety in reinforcement learning has become increasingly important in recent years. Yet, existing solutions either fail to strictly avoid choosing unsafe actions, which may lead to catastrophic results in safety-critical systems, or fail to provide regret guarantees for settings where safety constra…
Wrist kinematics estimation with muscle signals is a key issue in the field of wearable robots. In this study, we proposed a musculoskeletal-based-method driven by the Electrical Impedance Tomography (EIT) signals for continuously estimating wrist flexion/extension angles. The EIT-based interface ca
This paper studies adversarial bandits with corruptions. In the basic adversarial bandit setting, the reward of arms is predetermined by an adversary who is oblivious to the learner’s policy. In this paper, we consider an extended setting in which an attacker sits in-between the environment and the…
Learning to plan for long horizons is a central challenge in episodic reinforcement learning problems. A fundamental question is to understand how the difficulty of the problem scales as the horizon increases. Here the natural measure of sample complexity is a normalized one: we are interested in th…
It is believed that a model-based approach for reinforcement learning (RL) is the key to reduce sample complexity. However, the understanding of the sample optimality of model-based RL is still largely missing, even for the linear case. This work considers sample complexity of finding an $\epsilon$-…
Model-based reinforcement learning (RL), which finds an optimal policy using an empirical model, has long been recognized as one of the cornerstones of RL. It is especially suitable for multi-agent RL (MARL), as it naturally decouples the learning and the planning phases, and avoids the non-stationa…
This paper studies model-based reinforcement learning (RL) for regret minimization. We focus on finite-horizon episodic RL where the transition model $P$ belongs to a known family of models $\mathcal{P}$, a special case of which is when models in $\mathcal{P}$ take the form of linear mixtures: $P_{\…
We give a row sampling algorithm for the quantile loss function with sample complexity nearly linear in the dimensionality of the data, improving upon the previous best algorithm whose sampling complexity has at least cubic dependence on the dimensionality. Based upon our row sampling algorithm, we…
Regularization for optimization is a crucial technique to avoid overfitting in machine learning. In order to obtain the best performance, we usually train a model by tuning the regularization parameters. It becomes costly, however, when a single round of training takes significant amount of time. Ve…
Reward-free reinforcement learning (RL) is a framework which is suitable for both the batch RL setting and the setting where there are many reward functions of interest. During the exploration phase, an agent collects samples without using a pre-specified reward function. After the exploration phase…
Standard sequential decision-making paradigms aim to maximize the cumulative reward when interacting with the unknown environment., i.e., maximize $\sum_{h = 1}^H r_h$ where $H$ is the planning horizon. However, this paradigm fails to model important practical applications, e.g., safe control that a…
Preference-based Reinforcement Learning (PbRL) replaces reward values in traditional reinforcement learning by preferences to better elicit human opinion on the target objective, especially when numerical reward values are hard to design or interpret. Despite promising results in applications, the…
Motivated by the prevailing paradigm of using unsupervised learning for efficient exploration in reinforcement learning (RL) problems [tang2017exploration,bellemare2016unifying], we investigate when this paradigm is provably efficient. We study episodic Markov decision processes with rich observatio…
Exploration in reinforcement learning (RL) suffers from the curse of dimensionality when the state-action space is large. A common practice is to parameterize the high-dimensional value and policy functions using given features. However existing methods either have no theoretical guarantee or suffer…
Value function approximation has demonstrated phenomenal empirical success in reinforcement learning (RL). Nevertheless, despite a handful of recent progress on developing theory for RL with linear function approximation, the understanding of \emph{general} function approximation schemes largely rem…
Suppose we are given a large matrix $A=(a_{i,j})$ that cannot be stored in memory but is in a disk or is presented in a data stream. However, we need to compute a matrix decomposition of the entry-wisely transformed matrix, $f(A):=(f(a_{i,j}))$ for some function $f$. Is it possible to do it in a spa…
In this paper we settle the sampling complexity of solving discounted two-player turn-based zero-sum stochastic games up to polylogarithmic factors. Given a stochastic game with discount factor $\gamma\in(0,1)$ we provide an algorithm that computes an $\epsilon$-optimal strategy with high-probabili…
Imitation learning (IL) aims to mimic the behavior of an expert policy in a sequential decision-making problem given only demonstrations. In this paper, we focus on understanding the minimax statistical limits of IL in episodic Markov Decision Processes (MDPs). We first consider the setting where th…
We provide efficient algorithms for overconstrained linear regression problems with size $n \times d$ when the loss function is a symmetric norm (a norm invariant under sign-flips and coordinate-permutations). An important class of symmetric norms are Orlicz norms, where for a function $G$ and a ve…
We study constrained nonconvex optimization problems in machine learning and signal processing. It is well-known that these problems can be rewritten to a min-max problem in a Lagrangian form. However, due to the lack of convexity, their landscape is not well understood and how to find the stable eq…
Finding the reduced-dimensional structure is critical to understanding complex networks. Existing approaches such as spectral clustering are applicable only when the full network is explicitly observed. In this paper, we focus on the online factorization and partition of implicit large lumpable netw…
The goal of MRI reconstruction is to restore a high fidelity image from partially observed measurements. This partial view naturally induces reconstruction uncertainty that can only be reduced by acquiring additional measurements. In this paper, we present a novel method for MRI reconstruction that,…
Consider a Markov decision process (MDP) that admits a set of state-action features, which can linearly express the process’s probabilistic transition model. We propose a parametric Q-learning algorithm that finds an approximate-optimal policy using a sample size proportional to the feature dimensio…
Stochastic optimization naturally arises in machine learning. Efficient algorithms with provable guarantees, however, are still largely missing, when the objective function is nonconvex and the data points are dependent. This paper studies this fundamental challenge through a streaming PCA problem f…
A central problem in mining massive data streams is characterizing which functions of an underlying frequency vector can be approximated efficiently. Given the prevalence of large scale linear algebra problems in machine learning, recently there has been considerable effort in extending this data st…
In this paper we consider the problem of computing an $\epsilon$-optimal policy of a discounted Markov Decision Process (DMDP) provided we can only access its transition function through a generative sampling model that given any state-action pair samples from the transition function in $O(1)$ time.…
This paper presents a novel method to deal with the challenging task of generating photographic images conditioned on semantic image descriptions. Our method introduces accompanying hierarchical-nested adversarial objectives inside the network hierarchies, which regularize mid-level representations…
With pervasive applications of medical imaging in healthcare, biomedical image segmentation plays a central role in quantitative analysis, clinical diagnosis, and medical intervention. Since manual annotation suffers limited reproducibility, arduous efforts, and excessive time, automatic segmentatio…
We use differential equations based approaches to provide some {\it \textbf{physics}} insights into analyzing the dynamics of popular optimization algorithms in machine learning. In particular, we study gradient descent, proximal gradient descent, coordinate gradient descent, proximal coordinate gra…
Synthesized medical images have several important applications, e.g., as an intermedium in cross-modality image registration and as supplementary training samples to boost the generalization capability of a classifier. Especially, synthesized CT data can provide X-ray attenuation map for radiation t…
The inability to interpret the model prediction in semantically and visually meaningful ways is a well-known shortcoming of most existing computer-aided diagnosis methods. In this paper, we propose MDNet to establish a direct multimodal mapping between medical images and diagnostic reports that can…
We propose a DC proximal Newton algorithm for solving nonconvex regularized sparse learning problems in high dimensions. Our proposed algorithm integrates the proximal newton algorithm with multi-stage convex relaxation based on the difference of convex (DC) programming, and enjoys both strong comp…
Segmentation of 3D images is a fundamental problem in biomedical image analysis. Deep learning (DL) approaches have achieved the state-of-the-art segmentation performance. To exploit the 3D contexts using neural networks, known DL segmentation methods, including 3D convolution, 2D convolution on the…
Supervised contour detection methods usually require many labeled training images to obtain satisfactory performance. However, a large set of annotated data might be unavailable or extremely labor intensive. In this paper, we investigate the usage of semi-supervised learning (SSL) to obtain competit…
Computer-aided diagnosis of medical images requires thorough analysis of image details. For example, examining all cells enables fine-grained categorization of histopathological images. Traditional computational methods may have efficiency issues when performing such detailed analysis. In this paper…